Vol. 37 No. 1, 1998

Alcohol Preference Genetics in the House Mouse

Rachel L. Derr, Jeremy L. Peirce and Lee M. Silver*

Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA

Rachel L. Derr, Jeremy L. Peirce and Lee M. Silver (1998) Various strains of inbred mice show strain-specific and widely varying levels of alcohol consumption. Most strains consume moderate levels of ethanol; however, C57BL/6 mice consume ethanol at very high levels and DBA/2 mice consume ethanol at very low levels. We have mapped several loci, 1 located on chromosome 2 and 1 on chromosome 11, which are involved in this phenotype. We outline here the progress of this research and our strategy for higher-resolution mapping and analysis of the loci discovered.

Key words: Ethanol, C57BL/6, DBA/2, Mice, 2-bottle choice.

*Correspondence: Tel:(1609) 2585979. Fax: (1609) 2580975. E-mail: lsilver@molbiol.princeton.edu