Within the family Cyclocyprididae, Cypria and Physocypria are the classic genera, but new genera like Brasilocypria, Dentocypria, and Keysercypria have emerged with similar shell traits but differing appendage morphology. A new exotic genus and species (Vizcainocypria viator) described from the SE Iberian Peninsula (but probably of North American origin) exhibit similarities with these genera but shows differences in soft parts, especially the copulatory apparatus. The paper reviews the systematics of these controversial genera, highlighting diagnostic characters, providing family and generic keys, and presents the first molecular phylogenetic analysis of Cyclocyprididae using newly produced and online data. The integrative taxonomy approach contributes to understanding this challenging group with limited molecular data.