Alcohol Preference Genetics in the House Mouse
Rachel L. Derr, Jeremy L. Peirce and Lee M. Silver (1998) Various strains of inbred mice show strain-specific and widely varying levels of alcohol consumption. Most strains consume moderate levels of ethanol; however, C57BL/6 mice consume ethanol at very high levels and DBA/2 mice consume ethanol at very low levels. We have mapped several loci, 1 located on chromosome 2 and 1 on chromosome 11, which are involved in this phenotype. We outline here the progress of this research and our strategy for higher-resolution mapping and analysis of the loci discovered.
Keywords
Ethanol, C57BL/6, DBA/2, Mice, 2-bottle choice.
