[Review Article] Transgenic Fish: Ideal Models for Basic Research and Biotechnological Applications
Thomas T. Chen
Center of Marine Biotechnology, University of Maryland Biotechnology Institute and Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA
Current address: Biotechnology Center, The University of Connecticut, 184 Auditorium Road, U-149, Storrs, CT 06269-3149, USA
Jenn-Kan Lu
Center of Marine Biotechnology, University of Maryland Biotechnology Institute and Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA
Mike J. Shamblott
Center of Marine Biotechnology, University of Maryland Biotechnology Institute and Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA
Clara M. Chenq
Center of Marine Biotechnology, University of Maryland Biotechnology Institute and Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA
Chun-Mean Lin
Center of Marine Biotechnology, University of Maryland Biotechnology Institute and Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD, USA
Jane C. Burns
Department of Pediatrics, School of Medicine, University of California, San Diego, CA, USA
Renate Heimschuessel
Aquatic Pathobiology Group, Department of Pathology, University of Maryland at Baltimore, MD, USA
Nagaraj Chatakcndi
Department of Fisheries Science and Allied Aquaculture, Auburn University, Auburn, AL, USA
Rex A. Dunham
Department of Fisheries Science and Allied Aquaculture, Auburn University, Auburn, AL, USA
Organisms into which heterologous DNA has been artifically introduced and stably integrated in their genomes are termed transgenic. Since 1985, a wide variety of transgenic fish species have been produced by microinjecting or electroporation into fertilized or unfertilized eggs. These transgenic fish can serve as excellent experimental models for basic scientific investigations as well as biotechnical applications. In this paper, using research results generated in our laboratories and those of others as examples, we will review the current status of the transgenic fish research and illustrate the potential application of this technology in both basic research and biotechnological applications.
